Priti Saxena
Assistant Professor
Faculty of Life Sciences and Biotechnology (FLSB)

This email address is being protected from spambots. You need JavaScript enabled to view it.

Profile

RESEARCH EXPERIENCE:
Scientist Fellow: Institute of Genomics and Integrative Biology, Delhi (2009-2011)
Research Associate: National Institute of Immunology (NII), New Delhi (2008-2009)
Research Assistant: National Institute of Immunology (NII), New Delhi (2000-2003)

RESEARCH INTERESTS:
Infectious Biology with a focus on pathogenesis of tuberculosis and related mycobacterial diseases.

Qualifications

  • PhD in Chemical Biology from National Institute of Immunology, New Delhi , in 2008
  • M.Sc. in Microbiology from Institute of Microbiology & Biotechnology, Bhopal , in 2000

Awards & Honours

  • Honored with 'Science Initiator Award - 2015' for presenting the work entitled “Mechanistic Versatility of Corynebacterineae Type III Polyketide Synthases” at the 'International Conference on Innovative Approaches in Applied Sciences and Technologies' (iCiAsT-2016) organized at Kasetsart University, Bangkok, Thailand during February 1-5, 2016
  • Awarded the ‘Best Speaker Award’ in Young Scientist category for presenting the talk entitled “Molecular Diversity in Mycobacterial Pathogenesis” at UGC-Resource Networking National Symposium on ‘Microbes in Health and Agriculture’, MHA-2012, organized by School of Life Sciences, Jawaharlal Nehru University, New Delhi, India during March 12-13, 2012
  • Innovative Young Biotechnologist Award (IYBA) by the Department of Biotechnology, Ministry of Science and Technology, Government of India.
  • SAU Start-Up Research Grant by South Asian University, New Delhi, India.

Recent Publications

  • Pratap, S., Kant, A., Giri, S., Giri, G.R., Saxena, P.*, Krishnan, V.*. Crystal structure of type III polyketide synthase from Mycobacterium marinum, PDB ID: 5ZQ9, RCSB Protein Data Bank. (2018).

  • Parvez, A., Giri, S., Bisht, R. & Saxena, P.*. New Insights on Cyclization Specificity of Fungal Type III Polyketide Synthase, PKSIIINc in Neurospora crassa, Indian Journal of Microbiology. (April 27, 2018). doi: 10.1007/s12088-018-0738-9.

  • Parvez, A., Giri, S., Giri, G.R., Kumari, M., Bisht, R. & Saxena, P.*. Novel Type III Polyketide Synthases Biosynthesize Methylated Polyketides in Mycobacterium marinum, Nature Scientific Reports. 8(1):6529, April 25 (2018). doi: 10.1038/s41598-018-24980-1.

  • Saxena, P., Giri, S., Parvez, A., Giri, G.R. and Bisht, R. Methodology for Production of Acylphloroglucinol or Analogues using Microorganisms, Intellectual Property India, Indian Patent Application No. 201811013921 (2018).

  • Saxena, P., Giri, S., Parvez, A., Giri, G.R. and Bisht, R. Methodology for Production of Alkylresorcinol or Analogues using Microorganisms, Intellectual Property India, Indian Patent Application No. 201811013918 (2018).

  • Parvez, A., Bisht, R. & Saxena, P.*. Classification of Bacterial Type III Polyketide Synthases on the Basis of Cluster Organization in the Genome, Conference Proceedings of iCiAsT-2016, Bangkok, Thailand, February 1-5 (2016).

  • Saxena, P.*, Goyal, A. *, Rahman, A., Singh, P.K., Kasbekar, D.P., Gokhale, R.S. & Sankaranarayanan, R. Structural insights into biosynthesis of resorcinolic lipids by a type III polyketide synthase in Neurospora crassa, Journal of Structural Biology. 162(3):411-421, June (2008). (* equal authorship)

  • Gokhale, R.S., Saxena, P., Chopra, T. & Mohanty, D. Versatile polyketide enzymatic machinery for biosynthesis of complex mycobacterial lipids, Natural Product Reports. 24(2):267-277, April (2007).

  • Krithika, R., Marathe, U., Saxena, P., Ansari, M.Z., Mohanty, D. & Gokhale, R.S. A genetic locus required for iron acquisition in Mycobacterium tuberculosis, Proceedings of the National Academy of Sciences, USA. 103(7):2069, February 14 (2006).

  • Arora, P., Vats, A., Saxena, P., Mohanty, D. &Gokhale, R.S. Promiscuous fatty acyl CoA ligases produce acyl-CoA and acyl-SNAC precursors for polyketide biosynthesis, Journal of the American Chemical Society. Vol. 127, No. 26, July 6, pp. 9388-9389 (2005).

  • Sankaranarayanan, R., Saxena, P., Marathe, U.B., Gokhale, R.S., Shanmugam, V.M. &Rukmini, R. A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites, Nature Structural & Molecular Biology, Vol. 11, No. 9, September 9, pp. 894-900 (2004).

  • Rukmini, R., Shanmugam, V.M., Saxena, P., Gokhale, R.S. &Sankaranarayanan, R. Crystallization and preliminary X-ray crystallographic investigations of an unusual type III polyketide synthase PKS18 from Mycobacterium tuberculosis, ActaCrystallographica D Biological Crystallography. Vol. 60, Part 4, April, pp. 749-751, (2004).

  • Saxena, P., Yadav, G., Mohanty, D. &Gokhale, R.S. A new family of type III polyketide synthases in Mycobacterium tuberculosis, The Journal of Biological Chemistry, Vol. 278, No. 45, November 7, pp. 44780-44790 (2003).

Research Interests

  • Infectious Biology with a focus on pathogenesis of tuberculosis and related mycobacterial diseases.

^ Back to Top