Ravi Shankar Akundi
Assistant Professor
Faculty of Life Sciences and Biotechnology (FLSB)
Neuroinflammation Research Lab,
Akbar Bhawan,Room No.336,
Chanakyapuri ,New Delhi-110021

This email address is being protected from spambots. You need JavaScript enabled to view it.
Personal Webpage

Profile

RESEARCH EXPERIENCE1. Postdoctoral scholar: Dept of Anatomy & Neurobiology, University of Kentucky, Lexington, USA (2008-2012)2. Postdoctoral fellow (American Heart Association Fellowship): Yale Child Health Research Centre, Yale University, USA (2005-2008)

Qualifications

  • PhD in Biology from University of Freiburg Medical School, Freiburg, Germany , in 2005
  • M.Sc. in Biotechnology from Indian Institute of Technology (Bombay), Mumbai , in 1998-2000
  • B.Sc. from Andhra University,Visakhapatnam in 1998

Awards & Honours

  • Co-investigator for the proposal entitled “Development of v-type nerve agent hydrolysing enzyme” by the Life Sciences Research Board, Defence Research and Development Organization (DRDO),Government of India (2017-2020)
  • Extramural Research Grant for the Project entitled “Investigating the role of exogenous ATP in modulating inflammation in the rodent brain” from Science and Engineering Research Board,Department of Science and Technology (DST), Government of India (2017-2020)
  • Grants-in- aid for the proposal entitled “Investigating the role of exogenous ATP in cancer metastasis” by the Council of Scientific and Industrial Research (CSIR), Government of India (2017-2020)
  • Institute for South Asian Studies Grant for the Indo-Nepal project on “Sickle cell anaemia and its coexistence with alpha and beta thalassemia in a cohort of indigenous Tharu population of Nepal:
    Implications for the South Asian region” from the Institute for South Asian Studies, South Asian University, New Delhi (2016-2018)
  • Start Up grant for the project “P2- receptor mediated modulation of prostaglandin E2 synthesis in rodent brain” from South Asian University, New Delhi (2013-2016)
  • Parkinson’s Action Network Scholarship, Parkinson’s Action Network, Washington DC, USA (2012)
  • Heritage Post-doctoral Fellowship, American Heart Association, USA (2006-08)

Recent Publications

  • Agnihotri SK, Sun L, Yee BK, Shen R, Akundi RS, Zhi L, Duncan MJ, Cass WA, Bueler H (2019) Pink1 deficiency is associated with increased deficits of adult hippocampal neurogenesis and lowers the threshold for stress-induced depression in mice. Behavioural Brain Research 363:161-172.
  • Sharma S, Akundi RS* (2018) Mitochondria: A connecting link in the major depressive disorder jigsaw. Current Neuropharmacology 16.
  • Sharma RK, Candelario-Jalil E, Feineis D, Bringmann G, Fiebich BL, Akundi RS* (2017) 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) alters cell cycle progression in human neuroblastoma cell lines. Neurotoxicology Research, 32(4):649-660.
  • Fiebich BL,Akter S,Akundi RS* (2014) The two-hit hypothesis for neuroinflammation : role of exogenous ATP in madulating inflammation in the brain. Frontiers in Cellular Neuroscience 8, 260. (* Corresponding author) (2014)
  • Akundi RS,Zhi L,Sullivan PG,Bueler H (2013) shared and cell type-specific mitochondrial defects and metabolic adaptations in primary cells from Pink1-deficient mice.Neurodegenerative Diseases 12:136-49 (2013)
  • Ellis GI,Zhi L,Akundi R,Bueler H, Marti F (2013) Mitochondrial and cytosolic roles of PINK1 shape induced regulatory T cell development and function. European journal of Immunology 43:3355-60. (2013)
  • Shridas P,Zhi L,Akundi RS,Webb NR,Pearson KJ,Bueler H. PTEN-induced kinase 1 regulates mitochondrial intergrity and insulin secretion in mouse pancreatic beta cells.Journal of Endocrinology,Diabetes and Obesity (2013),1(1):1007. (2013)
  • Akundi RS,Zhi L,Bueler H.PINK1 enhances insulin-like growth factor 1-dependent Akt signalling and Protection against apoptosis.,Neurobiology of Disease 2012; 45:469-478 (2012)
  • Akundi RS,Huang Z,Eason J,Pandya JD,Zhi L,Cass WA,Sullivan PG, Bueler H. Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice. PLoS One 2011; 6:e16038 (2011)
  • Akundi RS,Rivkees SA,Hypoxia alters cell cycle regulatory protein expression and includes premature maturation of oligodendrocyte Precursor cells. PLoS One 2009; 4:e4739 (2009)

Research Interests

  • Mitochondrial dynamics during early neurodegeneration.
  • Modulation of glial cell activity through adenosine and its metabolites.
  • Regulation of glucose during neurodegenerative disorders.

^ Back to Top