Yuba Raj Pokharel
Assistant professor
Faculty of Life Sciences and Biotechnology (FLSB)
Akbar Bhawan,Room No.335
Chanakyapuri,New Delhi-110021
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Room No.: 335

Profile

PROFESSIONAL EXPERIENCE: - Post-Doctoral researcher at Turku center for biotechnology, University of Turku and ABO Akademi, Turku Finland (2009 to 2012) - Postdoctoral Fellow at Chosun University, Gwangju South Korea (2009) - Founder Principal at Metropolitan Higher Secondary School & Metro College, New Baneshwor, Kathmandu, (2002 to 2005) - Lecturer at Amrit Science College, Tribhuban University (1998 to 2003) - Lecturer at Birendra Multiple Campus, Chitwan, Nepal (1997-1998)

Qualifications

  • PhD in Pharmacology from Chosun University, Gwangju, Republic of Korea , in 2009
  • M.Sc. in Botany from Central Department of Botany, Tribhuvan University, Kathmandu Nepal , in 1995

Recent Publications

  • Shibendra Kumar Lal Karna, Omar Faruq & Yuba Raj Pokharel. L-Nω-Nitroarginine Inhibits the Induction of Nitric Oxide Synthase (iNOS) and Cyclooxygenase-2 (COX-2) by Inhibiting NF-κB and AP-1 Activation in RAW 264.7 Cells. Drug Des 5:135 December 2016; doi: 104172/2169-0138.1000135.

  • Khag Raj Sharma, Shibendra Kumar Lal Karna, Surya Kant Kalauni & Yuba Raj Pokharel. Phytochemical Analysis and In Vitro Antimicrobial Screening of Some Selected Medicinal Plants of Nepal. Accepted in December 2016 in International Journal of Recent Scientific Research. Jan. 2017 Vol.8, Issue1 14986-14994.

  • Amit Sarder & Yuba Raj Pokharel. Synthetic Derivatives of Artimisinin and Cancer; Review.International Journal of Medicine and Biomedical Sciences 2016: 1(4): 12-16.

  • Khaga Raj Sharma, Achyut Adhikari, Almas Jabeen, Nida Dastagir, Surya Kant alauni, M. Iqbal Choudhary and Yuba Raj Pokharel. Immunomodulatory studies on triterpenoids from Scoparia dulcis Linn.Biochemistry and Pharmacology (Los Angel), 2015, 4-183.

  • Khag Raj Sharma, Surya Kant Kalauni, Suresh Awale & Yuba Raj Pokharel. In Vitro Free Radical Scavenging Activity of Methanol Extracts of Some Selected Medicinal Plants of Nepal.Austin J of Bitechnol Bioeng. Vol. 2 Issue 1-2015.

  • Yuba Raj Pokharel, Jani Saarela, Agnieszka Szwajda, Christian Rupp, Anne Rokka, Shibendra Kumar Lal Karna, Kaisa Teittinen, Garry Corthals, Olli Kallioniemi, Krister Wennerberg, Tero Aittokallio  and Jukka Westermarck. Relevance Rank Platform (RRP) for functional filtering of high contentn protein-protein interaction data. Mol Cell Proteomics. 2015 Dec;14(12):3274-83

  • Amit Sarder, Md. Khadem Ali and Yuba Raj Pokharel. Tissue Factor and Breast Cancer. Biosci Bioeng Commun 2015; 1:20-28.

  • Anchit Khanna, Otto Kauko, Camilla Böckelman, Ilona Schreck, Agnes Szwajda, Anni Laine, Johanna Partanen, Yuba R. Pokharel, Merja Helenius, Michael Russel, Caj Haglund, Kristina A. Cole, Juha Klefström, Tero Aittokallio, Carsten Weiss, Ari Ristimäki, Tapio Visakorpi1, Jukka Westermarck Chk1 inhibits tumor suppressor PP2A and promotes MYC activity in human malignancies. Cancer
    Research 2013 Nov. 73(22): 6757-69

  • Kim HS, Je JH, Son TG, Park HR, Ji ST, Pokharel YR, Jeon HM, Kang KW, Kang HS, Chang SC, Kim HS,Chung HY, Lee J. The hepatoprotective effects of adenine nucleotide translocator-2 against aging and oxidative stress. Free Radic Res. 2011.

  • Pokharel YR, Kim ND, Han HK, Oh WK, Kang KW. Increased ubiquitination of multidrug resistance 1 by ginsenoside Rd. (2010) Nutr Cancer; 62(2): 252-9.

  • Choi HK, Pokharel YR, Lim SC, Han HK, Ryu CS, Kim SK, Kwak MK, Kang KW. Inhibition of liver fibrosis by solubilized coenzyme Q10: Role of Nrf2 activation in inhibiting transforming growth factor-beta1 expression. (2009) Toxicol Appl Pharmacol. 240(3): 377-84.

  • Jeong HG, Pokharel YR, Lim SC, Hwang YP, Han EH, Yoon JH, Ahn SG, Lee KY, Kang KW. Novel role of Pin1 induction in type II collagen-mediated rheumatoid arthritis. (2009) J Immunol. 183(10):6689-97.

Research Interests

  • Role of Pin1 and its interacting proteins in prostate cancer progression
  • Protein - Protein interaction study of human cancer cell line by one-step strep-tag methods
  • Role of inducible nitric oxide synthase (iNOS) and cyclooxyginase-2 in inflammation and cancer
  • siRNA, Crispr/Cas9 & overexpression approach for the study of oncogenic functions of different novel gene and their interaction.
  • Development of anticancer drug from Artemisinin derived synthetic compounds.

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